ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect and mechanism of Buyanghuanwu decoction on platelet activating factor expression in spinal cord tissue of model of acute upper cervical spinal cord injury in rats.</p><p><b>METHODS</b>Sixty SPF grade 3-month-old female Wistar rats were randomly divided into sham operation group, model group, methylprednisolone group and Buyanghuanwu decoction (Traditional Chinese Medicine group, TCM), with 15 rats in each group. The first day after the modeling, the methylprednisolone group were treated by injection of the tail vein for a total of 24 h, the first dose of 30 mg/kg, followed by a dose of 5.4 mg/kg·h, and 1 time per 4 h. The traditional Chinese medicine group was prepared with a medium dose of Buyanghuanwu decoction granules which were prepared into a solution containing 2 g/ml of granules, 3.5 g/kg per day gavage, was equivalent to 1 time the amount of adult consumption. The model group and the sham operation group were given equal volume of normal saline for 2 times a day for 2 weeks. The recovery of nerve function was evaluated by BBB classification at 1, 3, 7, 14 days after treatment. The expression of PAF in the segment of spinal cord injury was detected by double antibody sandwich (ELISA) method at 1, 7, and 14 d postoperatively.</p><p><b>RESULTS</b>At the first day after treatment, BBB score in model, TCM and methylprednisolone groups were lower than that of sham operation group(<0.01), but there was no difference among the three groups(>0.05). At 7, 14 days afer treatment, BBB score in TCM and methylprednisolone groups were higher than that of model group significantly(<0.01); but there were no significant difference between TCM group and methylprednisolone group(>0.05). PAF expression in TCM group and methylprednisolone group were lower than that of model group at 7, 14 day afer treatment significantly (<0.05); but there were no significant difference between TCM group and methylprednisolone group (>0.05).</p><p><b>CONCLUSIONS</b>Buyanghuanwu decoction treatment after acute upper cervical spinal cord injury can significantly improve locomotor recovery by inhibiting the expression of PAF.</p>
ABSTRACT
581 cases of cholelithiasis were assigned to Western medicine group. Chinese herb group and Combined treatment group. The Western medicine group received oral administration of Trepihutorie, Ai Hou Dan Tong Tablet; The Chinese herb group were orally administrated self - formulated prescription Si Jin Pai Shi Decoction and Gan Dan Jie Shi Tablet; The combined treatment group were orally administrated Si Jin Pai Shi Decoction and received treatment with Tui An Yun Jing Instrument. Results showed that the therapeutic effect in the combined treatment group was the best, the all - stone ejection rate, total lithecbole rate and the total effective rate being ]6. 8'i%i, 49. 27%. 84. 82%, respectively; in the Chinese herb group was next, the three indexes being 11. 29%. 37. 10% and 67. 7%, respectively; in the Western medicine group was the worst, the three indexes being 2. 44%, 7. 32% and 43. 90%. respectively. There were significantly differences in the all stone ejection rate (P